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GanedenBC30 may help support your digestive and immune health. And that's just great!

The more we learn about our intricate digestive system, the more we discover how closely tied it is to our overall health. An astounding 70 percent of your immune system is located in your digestive tract; it’s no surprise that research demonstrates that probiotics may boost our immunity. Clearly, probiotics help keep us healthy by more than just aiding digestion.

At Ganeden Biotech, we take science seriously

We have over 20 peer reviewed studies demonstrating the safety, efficacy and benefits of our signature probiotic strain, GanedenBC30  (Bacillus coagulans GBI-30, 6086). In addition, our on-site, research and development facility is one of the most advanced probiotic technological laboratories in the world. Our dedication to science ensures that you get the most stable, efficacious probiotic products available.

GanedenBC30 Research Highlights

SAFETY

Ganeden has conducted extensive safety studies on GanedenBC30, which have been published (Endres 2009, Endres2011) and culminated with Ganeden receiving FDA GRAS. These tests prove that even when GanedenBC30 is consumed at much higher levels than what is found in food and beverage products, that there are no safety concerns. FDA GRAS is strain specific, and GanedenBC30 is the only Bacillus that has been granted FDA GRAS status.

Safety Assessment Of A Proprietary Preparation Of A Novel Probiotic, Bacillus Coagulans, As A Food Ingredient
Food and Chemical Toxicology, 2009; 47: 1231–1238
J.R. Endresa, A. Clewella, K.A. Jadea, T. Farberb, J. Hauswirthc A.G. Schaussa

One-Year Chronic Oral Toxicity With Combined Reproduction Toxicity Study Of A Novel Probiotic, Bacillus Coagulans, As A Food Ingredient
Food and Chemical Toxicology Article in Press
J.R. Endresa, I. Qureshia, T. Farberb, J. Hauswirthc, G. Hirkad, I. Pasicsd, A.G. Schaussa

DIGESTIVE HEALTH

In multiple studies, GanedenBC30 supports digestive health when consumed daily:

A Prospective, Randomized, Double–blind, Placebo–controlled Parallel–group Dual Site Trial To Evaluate The Effects Of A Bacillus Coagulans–based Product On Functional Intestinal Gas Symptoms
BMC Gastroenterology, 2009, 9:85
Douglas S Kalman, Howard I Schwartz, Patricia Alvarez, Samantha Feldman, John C Pezzullo and Diane R Krieger

Survival And Metabolic Activity Of The GanedenBC30 Strain Of Bacillus Coagulans In A Dynamic In Vitro Model Of The Stomach And Small Intestine
Beneficial Microbes, 2010; 1(1): 31–36
A.J.H Maathuis, D. Keller, S. Farmer

Impact of GanedenBC30 (Bacillus coagulans GBI-30, 6086) on population dynamics of the human gut microbiota in a continuous culture fermentation system
International Journal of Probiotics and Prebiotics, 2011, 6 (1): 65-72
Harue Honda, Lesley Hoyles, Glenn R. Gibson, Sean Farmer, David Keller and Anne L. McCartney

Use Of A Continuous Culture Fermentation System To Investigate The Effect Of GanedenBC30 Bacillus Coagulans GBI-30, 6086) Supplementation On Pathogen Survival In The Human Gut Microbiota
Anarobe 2011, 17 (1): 36-42
H. Honda, G.R. Gibsona, S. Farmerb, D. Kellerb, A.L. McCartneya

Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice
Gut Pathogens, 2011, 3:16
Leo R Fitzpatrick, Jeffrey S Small, Wallace H Greene, Kelly D Karpa and David Keller

Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice
Gut Pathogens, 2012, 4:13
Leo R Fitzpatrick, Jeffrey S Small, Wallace H Greene, Kelly D Karpa, Sean Farmer and David Keller

Bacillus Coagulans Significantly Improved Abdominal Pain And Bloating In Patients With IBS
Postgraduate Medicine, 2009; 121(2): 119–124
Larysa Hun

Effects Of A Proprietary Bacillus Coagulans Preparation On Symptoms Of Diarrhea–Predominant Irritable Bowel Syndrome
Methods Find Exp Clin Pharmacol 2009; 31(10): 655–659
B.J. Dolin 

IMMUNE HEALTH

A large majority of the body’s immune system is located within the intestines. When GanedenBC30 is consumed daily, it creates a healthier intestinal environment, supporting immune function.

Bacillus coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women
The Journal of Nutrition May 2015
Edna P Nyangale, Sean Farmer, Howard A Cash, David Keller, David Chernoff, and Glenn R Gibson

Immunomodulation of Antiretroviral Drug-Suppressed Chronic HIV-1 Infection in an Oral Probiotic Double-Blind Placebo-Controlled Trial
AIDS Research and Human Retroviruses October 2014, 30(10): 988-995. doi:10.1089/aid.2014.0181.
Yang Otto O., Kelesidis Theodoros, Cordova Robert, and Khanlou Homayoon

GanedenBC30 Cell Wall And Metabolites: Anti–inflammatory And Immune Modulating Effects In vitro
BMC Immunology 2010, 11:15
Gitte S Jensen, Kathleen F Benson, Steve G Carter, John R Endres

Probiotic metabolites from Bacillus coagulans GanedenBC30 support maturation of antigen-presenting cells in vitro
World Journal of Gastroenterology, 2012, 18(16): 1875–1883
Kathleen F Benson, Kimberlee A Redman, Steve G Carter, David Keller, Sean Farmer, John R Endres and Gitte S Jensen

A review of probiotics studies in HIV research suggests improved immunological presentation and preservation of viral host restrictive factors of TH17 in HIV patients
Retrovirology, 2012, 9(Suppl 1):P22
M Selbovitz, Keller, Miller, Moore, Farmer and Bray

A Patented Strain Of Bacillus Coagulans Increased Immune Response To Viral Challenge
Postgraduate Medicine, 2009; 121(2): 114–118
Mira Baron

A Controlled Clinical Trial To Evaluate The Effect of GanedenBC30 On Immunological Markers
Methods and Findings in Experimental and Clinical Pharmacology 2010, 32(2): 129-132
M. Kimmel, D. Keller, S. Farmer, D.E. Warrino

ADDITIONAL BENEFITS

Probiotic Bacillus coagulans GBI-30, 6086 reduces exercise-induced muscle damage and increases recovery
PeerJ, July 2016‚Äč
Ralf Jäger, Kevin A. Shields, Ryan P. Lowery, Eduardo O. De Souza, Jeremy M. Partl, Chase Hollmer, Martin Purpura and Jacob M. Wilson

Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086
Anaerobe Volume 30, December 2014, Pages 75–81
Edna P. Nyangale, Sean Farmer, David Keller, David Chernoff, Glenn R. Gibson

Bacillus coagulans : A Viable Adjunct Therapy For Relieving Symptoms Of Rheumatoid Arthritis According To A Randomized, Controlled Trial
BMC Complementary and Alternative Medicine 2010, 10:1
David R Mandel, Katy Eichas, Judith Holmes

Bacillus Coagulans As A Probiotic
Food Science & Technology Bulletin: Functional Foods 2010, 7 (7): 103-109
D. Keller, S. Farmer, A.L. McCartney, G. Gibson

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